Tuesday, September 24, 2019

Importance of Vitamin D, Breast Cancer, It's Never Too Late To Exercise


THE GREATEST MEDICINE OF ALL IS TEACHING PEOPLE NOT TO NEED IT

Fall Reminder - It Is That Time of Year to Start Taking a Vitamin D supplement. Most natural doctors recommend taking at least 2,000 IU of D3 per day and up to 8,000 IU per day for shorter periods during an illness. Vitamin D helps strengthen your immune system to fight off colds and the flu along with many other benefits described below.
  
Low vitamin D linked to adolescent behavior problems

Children with vitamin D deficiency between the ages of 5 and 12 years were 1.8 times as likely to display behavior problems in later childhood, when they were 11 to 18 years old

Vitamin D was once regarded as a nutrient important for bone health, but it's now known that this steroid hormone influences virtually every cell in your body, including those in your brain. Far from just influencing your physical health, vitamin D plays a role in mental health and may influence behavior — even years down the road.

As such, ensuring children's vitamin D levels are optimized is also important, as a deficiency in childhood may affect their behavior in adolescence, according to a University of Michigan study.

Low vitamin D in childhood linked to behavior problems later

The study involved 273 school-aged children between the ages of 5 and 12 years, living in Bogota, Colombia, who were part of a larger cohort study that began in 2006 and involved follow-up interviews conducted after six years. Part of the interviews assessed the children's behavior, and the researchers also checked the children's vitamin D levels via blood samples that were collected at the start of the study.

Vitamin D deficiency, defined as a vitamin D level of less than 20 ng/mL (or 50 nmol/L) was found in 10.3% of the children. Further, those with a deficiency at the start of the study were 1.8 times as likely to display behavior problems in later childhood, when they were 11 to 18 years old.

"Children who have vitamin D deficiency during their elementary school years appear to have higher scores on tests that measure behavior problems when they reach adolescence," Eduardo Villamor, professor of epidemiology at the University of Michigan School of Public Health, said in a news release. This includes more "externalizing" problems, such as aggressive and rule-breaking behaviors.

Low levels of vitamin D binding protein, which transport vitamin D in the blood, were also linked to aggressive behavior and symptoms of anxiety and depressive mood compared to higher levels.

Vitamin D's connection to emotional and behavioral problems

Separate research was published in 2017 that also linked vitamin D to emotional and behavioral problems in adolescents. In an analysis of 9,068 participants, lower vitamin D status was associated with increased emotional problems, peer relationship issues and behavioral difficulties among children. Further, a slight increase in vitamin D (10 ng/ml for boys and 10.2 ng/ml for girls) was linked to a decrease in total behavioral difficulties.

Vitamin D receptors exist in the human brain, hinting at the importance of this vitamin in mental and emotional health. It's believed that vitamin D regulates more than 200 different genes by binding to vitamin D receptors that are responsible for driving a number of biological processes. Low levels of vitamin D have, in fact, been linked to a number of psychological disorders, including anxiety, depression and schizophrenia.

It likely influences psychological health in a number of ways, including by modulating inflammation, regulating proteins that fight free radicals and increasing the synthesis of brain-derived neurotrophic factor, which may play a role in schizophrenia.

Taken together, vitamin D exerts a neuroprotective role in the brain. Writing in the journal Children, Dr. Joy Weydert of the department of pediatrics at the University of Kansas Medical Center explained:

"Activated vitamin D also has neuroprotective effects via neuromodulation, anti-inflammatory, anti-ischemic, and anti-oxidant properties. Having adequate vitamin D levels in-utero and early stages of life ensures normal receptor transcriptional activity vital for brain development and mental functioning.

Vitamin D affects the proteins directly involved in learning, memory, motor control, and social behavior, and is closely associated with executive functioning such as goal-directed behavior, attention, and adaptability to change."

Vitamin D deficiency in utero may harm the brain

Getting enough vitamin D, via sensible sun exposure or supplementation, is one of the most straightforward strategies you can use to protect mental health, and this is true even in utero. In one study, children who were vitamin D deficient at birth had a 44% increased risk of developing schizophrenia as adults.

"Lack of vitamin D during brain development may alter a number of outcomes, including brain volume, neurochemistry, the expression of genes and proteins and behavior, the researchers explained.

Weydert added:
"Studies are starting to reveal the neurohormonal effects of vitamin D on brain development and behavior, with a link to mental health disorders. Many of these effects start well before the birth of the child, so it is important that each pregnant woman be assessed for vitamin D deficiency and supplemented for the best possible health outcome of the child."

Along with behavior problems and schizophrenia, other mental health problems associated with vitamin D deficiency include depression, seasonal effective disorder and autism.

How much vitamin D is ideal?

The level you're aiming for is between 60 and 80 ng/mL, with 40 ng/mL being the low cutoff point for sufficiency to prevent a wide range of diseases, including cancer. Yet, as Weydert noted, "Current recommended doses of vitamin D supplementation fall short of what is needed to obtain ideal serum levels."

Research suggests it would require 9,600 IUs of vitamin D per day to get 97.5% of the population to reach 40 ng/mL,20 but individual requirements can vary widely, and you'll need to get your levels tested to ensure you take the correct dosage required to get you into the optimal range.

Regular sunlight exposure is the ideal way to optimize your vitamin D (as well as glean the other health benefits of sun exposure), but many people have difficulty getting out in the sun, whether it's due to working indoors, weather or physical limitations. As such, many will need to take an oral vitamin D3 supplement, especially during winter months.

The only way to gauge whether you might need to supplement, and how much, is to get your level tested, ideally twice a year, in the early spring, after the winter, and early fall when you level is at its peak and low point.

GrassrootsHealth makes testing easy by offering an inexpensive vitamin D testing kit as part of its consumer-sponsored research. By signing up, you are helping further vital health research that can help millions in coming years.  

GrassrootsHeallth is also working to end vitamin D deficiency in children and pregnant women, and believes a new standard of care should be implemented for pregnant women that involves vitamin D testing three times during pregnancy and maintaining blood levels of 40 to 60 ng/mL.

Although such testing is not yet widespread, you can request a vitamin D blood test from your health care provider or, if you're a woman who is between 12 to 17 weeks pregnant, enroll in GrassrootsHealth's Protect Our Children NOW! Project.

Vitamin D deficiency is widespread

Research has shown that once you reach a minimum serum vitamin D level of 40 ng/mL, your risk for cancer diminishes by 67%, compared to having a level of 20 ng/mL or less. If the deficiency cutoff were to be moved to 40 to 60 ng/mL, vitamin D deficiency rates in the U.S. would skyrocket.

Even using 20 ng/mL, vitamin D deficiency in children is "very common," and children, like adults, should obtain regular sun exposure or take vitamin D3 supplements to ensure their levels are in the optimal range. It's important to note that vitamin D supplementation must be balanced with other nutrients, namely vitamin K2 (to avoid complications associated with excessive calcification in your arteries), calcium and magnesium.

Optimizing vitamin D is essential for overall health

The finding that low vitamin D in childhood may lead to behavioral problems in adolescence highlights the importance of maintaining optimal vitamin D throughout life. Beyond its effects on mental health, a deficiency in vitamin D has been implicated in such problems as multiple sclerosis and chronic heart failure.

Vitamin D also significantly reduces oxidative stress in your vascular system, which can prevent the development of heart disease. In addition, optimizing your vitamin D levels is one of the absolute best flu prevention strategies available and can also slash your cancer risk.

Previous research found that a vitamin D level of 47 ng/ml was associated with a 50% lower risk of breast cancer, for instance. Vitamin D has a favorable effect on immune health, mental health and life expectancy, and, overall, if everyone in North America optimized their vitamin D levels, it's estimated that:

  • All-cancer incidence rates would decrease by 25%
  • Influenza and pneumonia rates would decrease by 30%
  • Septicemia would decrease 25%
  • Multiple sclerosis would decrease by 40%
  • Negative pregnancy outcomes (including asthma, infections, bone disorders, heart failure and autism in the baby) would be reduced by 10%
If you're unsure of your own, or your children's, vitamin D levels, getting your levels checked is the first step to optimization. Weydert goes so far as to state, "One can choose to measure 25(OH)D levels to document vitamin D deficiency, but with the widespread findings of insufficiency and deficiency in most cultures, it is relatively safe to start vitamin D supplementation without this information."

That being said, if you opt to go this route, be sure to get levels tested going forward, so you can determine the right vitamin D dose to maintain optimal levels.

A growing body of evidence shows that vitamin D plays a crucial role in disease prevention and maintaining optimal health. There are about 30,000 genes in your body, and vitamin D affects nearly 3,000 of them, as well as vitamin D receptors located throughout your body.

According to one large-scale study, having optimal vitamin D levels can slash your risk of cancer and can help prevent at least 16 different types of cancer, including pancreatic, lung, ovarian, prostate and skin cancers.

Vitamin D from sun exposure also radically decreases your risk of autoimmune diseases like multiple sclerosis (MS) and Type 1 diabetes. Sun exposure also helps prevent osteoporosis, which is a significant concern for women in particular.

Meanwhile, recent research suggests high doses (4 grams) of the omega-3 fats EPA and DHA may help improve healing after a heart attack. Other benefits of omega-3 fats include prevention of lupus and Parkinson’s disease, decreased anxiety, healthier and stronger bones, as well as fighting fats in the body.

With these facts, it’s clear that vitamin D and omega-3 fatty acids are two of the most important nutrients your body needs to maintain optimal health. However, you can’t tell by looking in a mirror if you are deficient in vitamin D or omega-3s. The only real way to know if you are deficient in these nutrients is to get tested.


The biology of breast cancer
By Marc S. Micozzi, M.D., Ph.D.

The modern breast cancer epidemic was raising its head. Of course, biologists knew that declining birth rates (and increased duration of exposure to estrogen) was the real, major risk factor behind the rapid increase in breast cancer rates.

In fact, even in the mid-1980s, we had known for years that the biggest risk factors for breast cancer are:
  • Earlier age at menarche
  • Later age at menopause
  • Having fewer or no pregnancies
  • Becoming pregnant later in life
  • Not breastfeeding
As you can see, reproductive hormones are at the heart of all of these risk factors. And it makes sense, as biology shows that increased, lifelong exposure to estrogen increases the risk of breast cancer.

In fact, back in the 1970s at the Senate Hearings on birth control pills, Dr. Roy Hertz warned that estrogens, "are to breast cancer what fertilizer is to the wheat crop." And that analogy really put the problem in terms the midwestern Senator, who led the committee hearings, could relate to. (At the same hearings, Dr. Victor Wynn warned that all human carcinogens are latent. And it can take at least 10 to 20 years to determine the impact.)

Of course, one of the most common and fastest-growing types of breast cancer is typically called estrogen receptor-positive (ER+). It accounts for nearly 80 percent of cases.

Plus, new research shows that estrogen appears to make other tissues, like the brain, more susceptible to breast cancer metastasis. Which may explain why younger women, who have more estrogen, are more likely to suffer brain metastasis if they get breast cancer.

At one point, some scientists thought that switching to progesterone/progestin (the pregnancy hormone) OC would be safer. But about 65 percent of breast cancer tumors contain progesterone receptors and are called progesterone receptor-positive (PR+).

So, clearly, that's not a real solution. Plus, oncologists end up treating women diagnosed with these two types of breast cancer (ER+ and PR+) with Tamoxifen, a drug that blocks hormone receptors. (Essentially, the drug blocks the hormones that many of these women had been previously taking as OC!)

Despite this, it seems few people at the NCI are willing to confront the hormonal causes of breast cancer—even to this day.

Instead, as with other cancers, the NCI went on a wild goose chase, looking for other risk factors for breast cancer. Such as alcohol, dietary fat, dairy, eggs, meat, and protein.

Of course, none of the research really panned out.

And they still don't know what to tell worried women other than to get routine mammogram screenings, which can detect smaller and smaller breast growths, but don't save lives, according to the most recent research.

So, now that you understand a bit more about the history of OC and the biology of breast cancer, let's move onto the recent study…

Recent study shows OC poses clear, long-lasting threats to women

In the recent study, researchers analyzed results from 54 studies involving nearly 12,000 women as part of the African American Breast Cancer Epidemiology and Risk Consortium.

Researchers found that both recent use and long duration of prior use of hormonal contraceptives were strongly associated with an increased risk of breast cancer.

More specifically:

1. Women who had used OC within the past five years had a 78 percent increased risk of developing       triple-negative (TN) breast cancer, one of the deadliest and most aggressive types of breast cancer.

2. Women who took OC within the past five years had a 46 percent higher risk of developing ER+           breast cancer and estrogen negative-receptors (ER-), another type of cancer.

3. The ER+ breast cancer risk remained for 15 to 19 years after stopping OC use.

4. The ER- breast cancer risk remained beyond 19 years after stopping OC use.

So, at the end of the day, birth control pills raise breast cancer risk. And the risk can continue 20 years (or more) after you stop taking them!

This risk occurs because OCs prevent pregnancies (as intended). But as I explained earlier, pregnancy and fewer lifetime menstrual cycles have a clear anti-cancer effect. Birth control pills also present the double whammy of promoting breast cancer through their hormonal effects. Plus, they increase the risk of other health-related complications, such as blood clots.

Fortunately, there are many natural ways to reduce your breast cancer risk—and your risk of developing other types of cancer. We actually began learning about them in the mid-1990s…

In fact, in 1996, then-Senator Arlen Specter of Pennsylvania nominated me to serve as a U.S. representative to a Canadian Food and Drug Administration (FDA) panel on breast cancer. The Canadian panel found that botanicals, vitamins (such as vitamin D), and minerals significantly reduce a woman's risk of developing breast cancer. They also improve survival and quality of life in women with breast cancer.
  

Study Reveals It's Never Too Late to Start Exercising

The study, undertaken by researchers at the University of Birmingham in England, pitted lifelong athletes in their 70s and 80s against men of the same age who had never participated in a structured fitness program.

The goal was to find out whether untrained individuals have the capacity to build muscle to the extent that lifelong exercisers can. As noted in Neuroscience News, "The researchers … expected that the master athletes would have an increased ability to build muscle due to their superior levels of fitness over a prolonged period of time."

The answer is encouraging, to say the least, as muscle biopsies taken before and after exercise revealed both groups had the identical capacity to build muscle in response to exercise.

It's important to realize that without resistance training; your muscles will atrophy and lose mass. Age-related loss of muscle mass is known as sarcopenia, and if you don't do anything to stop it you can expect to lose about 15% of your muscle mass between your 30s and your 80s. Other benefits of resistance training include:

•  Improved walking ability — After 12 weeks of weight training, seniors aged 65 and over improved     leg strength and endurance, and were able to walk 38% farther without resting.

•  Improved ability to perform daily task. After 16 weeks of "total body" weight training, women     aged 60 to 77 years substantially increased their strength, improved their walking velocity and their     ability to carry out daily tasks, such as rising from a chair and carrying groceries.

•  Relief from joint pain - Weight training strengthens the muscles, tendons and ligaments around         your joints, which takes stress off the joint and helps ease pain. It can also help increase your range     of motion.

•  Improved blood sugar control - Weight training helps to control blood sugar levels in people with     Type 2 diabetes. It can also reduce your Type 2 diabetes risk. In one study, strength training for at       least 150 minutes a week lowered diabetes risk by 34% compared to being sedentary. Doing a             combination of weight training and aerobic exercise (such as brisk walking, jogging, bicycling,           swimming, tennis or rowing) lowered the risk by 59%.

•  Improved brain health and slowed brain aging - Resistance training also increases your body's         production of growth factors, which are responsible for cellular growth, proliferation, and                   differentiation.

Some of these growth factors also promote the growth, differentiation and survival of neurons, which helps explain why working your muscles also benefits your brain and helps prevent dementia.

Until next time, stay healthy and happy

JD Roma




The information on this blog is provided for educational purposes only. It is not a substitute for professional medical care, and medical advice and services are not being offered. If you have, or suspect you have, a health problem you should consult your physician (preferably a Naturopath).

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